Whole Genome Sequencing to Investigate the Emergence of Clonal Complex 23 Neisseria meningitidis Serogroup Y Disease in the United States
Identifieur interne : 000346 ( Main/Exploration ); précédent : 000345; suivant : 000347Whole Genome Sequencing to Investigate the Emergence of Clonal Complex 23 Neisseria meningitidis Serogroup Y Disease in the United States
Auteurs : Mary G. Krauland [États-Unis] ; Julie C. Dunning Hotopp [États-Unis] ; David R. Riley [États-Unis] ; Sean C. Daugherty [États-Unis] ; Jane W. Marsh [États-Unis] ; Nancy E. Messonnier [États-Unis] ; Leonard W. Mayer [États-Unis] ; Hervé Tettelin [États-Unis] ; Lee H. Harrison [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2012.
Abstract
In the United States, serogroup Y, ST-23 clonal complex
Url:
DOI: 10.1371/journal.pone.0035699
PubMed: 22558202
PubMed Central: 3338715
Affiliations:
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Dunning Hotopp</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>The Institute for Genome Sciences, University of Maryland School of Medicine, University of Maryland, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Institute for Genome Sciences, University of Maryland School of Medicine, University of Maryland, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Riley, David R" sort="Riley, David R" uniqKey="Riley D" first="David R." last="Riley">David R. 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Krauland</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Infectious Diseases Epidemiology Research Unit, School of Medicine and Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvanian, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Infectious Diseases Epidemiology Research Unit, School of Medicine and Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvanian</wicri:regionArea><orgName type="university">Université de Pittsburgh</orgName><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Hotopp, Julie C Dunning" sort="Hotopp, Julie C Dunning" uniqKey="Hotopp J" first="Julie C. Dunning" last="Hotopp">Julie C. Dunning Hotopp</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>The Institute for Genome Sciences, University of Maryland School of Medicine, University of Maryland, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Institute for Genome Sciences, University of Maryland School of Medicine, University of Maryland, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Riley, David R" sort="Riley, David R" uniqKey="Riley D" first="David R." last="Riley">David R. Riley</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>The Institute for Genome Sciences, University of Maryland School of Medicine, University of Maryland, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Institute for Genome Sciences, University of Maryland School of Medicine, University of Maryland, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Daugherty, Sean C" sort="Daugherty, Sean C" uniqKey="Daugherty S" first="Sean C." last="Daugherty">Sean C. Daugherty</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>The Institute for Genome Sciences, University of Maryland School of Medicine, University of Maryland, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Institute for Genome Sciences, University of Maryland School of Medicine, University of Maryland, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Marsh, Jane W" sort="Marsh, Jane W" uniqKey="Marsh J" first="Jane W." last="Marsh">Jane W. Marsh</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Infectious Diseases Epidemiology Research Unit, School of Medicine and Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvanian, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Infectious Diseases Epidemiology Research Unit, School of Medicine and Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvanian</wicri:regionArea><orgName type="university">Université de Pittsburgh</orgName><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Messonnier, Nancy E" sort="Messonnier, Nancy E" uniqKey="Messonnier N" first="Nancy E." last="Messonnier">Nancy E. Messonnier</name><affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>Meningitis and Vaccine Preventable Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Meningitis and Vaccine Preventable Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Mayer, Leonard W" sort="Mayer, Leonard W" uniqKey="Mayer L" first="Leonard W." last="Mayer">Leonard W. Mayer</name><affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>Meningitis and Vaccine Preventable Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Meningitis and Vaccine Preventable Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Tettelin, Herve" sort="Tettelin, Herve" uniqKey="Tettelin H" first="Hervé" last="Tettelin">Hervé Tettelin</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>The Institute for Genome Sciences, University of Maryland School of Medicine, University of Maryland, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Institute for Genome Sciences, University of Maryland School of Medicine, University of Maryland, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Harrison, Lee H" sort="Harrison, Lee H" uniqKey="Harrison L" first="Lee H." last="Harrison">Lee H. Harrison</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Infectious Diseases Epidemiology Research Unit, School of Medicine and Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvanian, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Infectious Diseases Epidemiology Research Unit, School of Medicine and Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvanian</wicri:regionArea><orgName type="university">Université de Pittsburgh</orgName><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In the United States, serogroup Y, ST-23 clonal complex <italic>Neisseria meningitidis</italic> was responsible for an increase in meningococcal disease incidence during the 1990s. This increase was accompanied by antigenic shift of three outer membrane proteins, with a decrease in the population that predominated in the early 1990s as a different population emerged later in that decade. To understand factors that may have been responsible for the emergence of serogroup Y disease, we used whole genome pyrosequencing to investigate genetic differences between isolates from early and late <italic>N. meningitidis</italic> populations, obtained from meningococcal disease cases in Maryland in the 1990s. The genomes of isolates from the early and late populations were highly similar, with 1231 of 1776 shared genes exhibiting 100% amino acid identity and an average π<sub>N</sub> = 0.0033 and average π<sub>S</sub> = 0.0216. However, differences were found in predicted proteins that affect pilin structure and antigen profile and in predicted proteins involved in iron acquisition and uptake. The observed changes are consistent with acquisition of new alleles through horizontal gene transfer. Changes in antigen profile due to the genetic differences found in this study likely allowed the late population to emerge due to escape from population immunity. These findings may predict which antigenic factors are important in the cyclic epidemiology of meningococcal disease.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Harrison, Lh" uniqKey="Harrison L">LH Harrison</name></author><author><name sortKey="Trotter, Cl" uniqKey="Trotter C">CL Trotter</name></author><author><name sortKey="Ramsay, Me" uniqKey="Ramsay M">ME Ramsay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harrison, Lh" uniqKey="Harrison L">LH Harrison</name></author><author><name sortKey="Jolley, Ka" uniqKey="Jolley K">KA Jolley</name></author><author><name sortKey="Shutt, Ka" uniqKey="Shutt K">KA Shutt</name></author><author><name sortKey="Marsh, Jw" uniqKey="Marsh J">JW Marsh</name></author><author><name sortKey="O Leary, M" uniqKey="O Leary M">M O'Leary</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jackson, La" uniqKey="Jackson L">LA 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uniqKey="Rutter K">K Rutter</name></author><author><name sortKey="Fitzpatrick, Sz" uniqKey="Fitzpatrick S">SZ Fitzpatrick</name></author><author><name sortKey="Srikhanta, Yn" uniqKey="Srikhanta Y">YN Srikhanta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, P" uniqKey="Zhu P">P Zhu</name></author><author><name sortKey="Van Der Ende, A" uniqKey="Van Der Ende A">A van der Ende</name></author><author><name sortKey="Falush, D" uniqKey="Falush D">D Falush</name></author><author><name sortKey="Brieske, N" uniqKey="Brieske N">N Brieske</name></author><author><name sortKey="Morelli, G" uniqKey="Morelli G">G Morelli</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li><li>Maryland</li><li>Pennsylvanie</li></region><settlement><li>Pittsburgh</li></settlement><orgName><li>Université de Pittsburgh</li></orgName></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Krauland, Mary G" sort="Krauland, Mary G" uniqKey="Krauland M" first="Mary G." last="Krauland">Mary G. Krauland</name></region><name sortKey="Daugherty, Sean C" sort="Daugherty, Sean C" uniqKey="Daugherty S" first="Sean C." last="Daugherty">Sean C. Daugherty</name><name sortKey="Harrison, Lee H" sort="Harrison, Lee H" uniqKey="Harrison L" first="Lee H." last="Harrison">Lee H. Harrison</name><name sortKey="Hotopp, Julie C Dunning" sort="Hotopp, Julie C Dunning" uniqKey="Hotopp J" first="Julie C. Dunning" last="Hotopp">Julie C. Dunning Hotopp</name><name sortKey="Marsh, Jane W" sort="Marsh, Jane W" uniqKey="Marsh J" first="Jane W." last="Marsh">Jane W. Marsh</name><name sortKey="Mayer, Leonard W" sort="Mayer, Leonard W" uniqKey="Mayer L" first="Leonard W." last="Mayer">Leonard W. Mayer</name><name sortKey="Messonnier, Nancy E" sort="Messonnier, Nancy E" uniqKey="Messonnier N" first="Nancy E." last="Messonnier">Nancy E. Messonnier</name><name sortKey="Riley, David R" sort="Riley, David R" uniqKey="Riley D" first="David R." last="Riley">David R. Riley</name><name sortKey="Tettelin, Herve" sort="Tettelin, Herve" uniqKey="Tettelin H" first="Hervé" last="Tettelin">Hervé Tettelin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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